Feedback Neuro-Modulation Technology

Neuro-Modulation Technology

i. Electrical Stimulation on the Animal Disease Model

We are interested in the chemical and behavioral changes underlying neuromodulation. Fast scan cyclic voltammetry (FSCV) is a reliable electrochemical technique for measuring how much dopamine, serotonin and other neurotransmitters release. In combination with a variety of behavioral and pharmacological techniques, FSCV makes it possible to investigate neurotransmission correlates to behavior and pharmacological manipulation. We apply this technique to rats for in-vivo studies with our wireless FSCV device called WINCS (Wireless Instantaneous Neurotransmitter Concentration Sensing System, Mayo Clinic, USA). We also are interested in the micro-devices for in-vivo studies. For measurement in freely moving animals, we are developing micro-drive which makes it possible to adjust depth of electrode. Combined with our wireless FSCV device we investigate neurotransmitter changes in freely moving animals.

ii. Ultrasound Neuro-Modulation Technology

Fig 1. Therapeutic method for neuropsychiatric disorders using focused ultrasound in human brain.

Several neuro-modulation technologies have received great attention due to their therapeutic abilities for neuropsychiatric disorders such as epilepsy, stroke, Parkinson’s disease, depression and many others. Especially, the noninvasive neuro-modulation technologies, like transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), are recently spotlighted by its major advantages-they do not require surgery. Despite their noninvasiveness, it is often preferred to implement brain stimulation methods that offer better spatial resolutions and targeting accuracies than those methods since noninvasive neuro-modulation technologies have low spatial resolutions and poor targeting accuracies. Some research recently showed that transcranial ultrasonic neuro-modulation method can functionally stimulate neural tissues without surgery and has better spatial resolutions and targeting accuracies than TMS and tDCS. By this advantage, ultrasound neuro-modulation represents a powerful new tool for neuro-engineering.

    Our goals for developing ultrasound neuro-modulation are
  • Investigating acoustic parameters for transcranial neural excitation or suppression.
  • Developing multifocal ultrasonic stimulation for patterned neuro-stimulation.
  • Developing therapeutic methods for neuropsychiatric disorders using ultrasonic neuro-modulation.
133-791, 서울특별시 성동구 행당동 17 한양대학교    Tel 02.2253.1670    Fax 02.2253.1671